BPC-157 (Body Protection Compound-157)
A synthetic pentadecapeptide derived from human gastric juice protein, widely studied in tissue repair and gastrointestinal research.
Overview
BPC-157 is a 15-amino-acid peptide (sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) originally isolated as a partial sequence from human gastric juice. It has been the subject of over 100 published preclinical studies investigating its effects on various tissue repair and cytoprotective mechanisms.
Unlike many other peptides studied in this field, BPC-157 is stable in human gastric juice, which has made it a subject of particular interest in gastrointestinal research.
Molecular Profile
Mechanism of Action
Research has identified several pathways through which BPC-157 exerts its effects in preclinical models:
- Nitric oxide (NO) system:Studies have demonstrated BPC-157's interaction with the NO system, influencing vascular tone and angiogenesis pathways (Seiwerth et al., 2018).
- Growth factor modulation: Research has shown upregulation of growth factor expression including EGF, VEGF, and FGF in tissue models treated with BPC-157 (Sikiric et al., 2016).
- FAK-paxillin pathway: BPC-157 has been observed to activate the FAK-paxillin signalling cascade, which plays a role in cell migration and adhesion (Hsieh et al., 2017).
- Dopaminergic system:Preclinical studies have investigated BPC-157's interaction with dopamine systems, particularly in models of dopamine-related dysfunction (Sikiric et al., 2010).
Key Published Research
Stable gastric pentadecapeptide BPC 157: Novel therapy in gastrointestinal tract
Sikiric P, et al. Current Pharmaceutical Design. 2018; 24(18):2012-2032
Review of BPC-157's effects on gastrointestinal lesions, fistulas, and inflammatory processes across multiple preclinical models.
BPC-157 and its role in accelerating wound healing
Cerovecki T, et al. Medical Science Monitor Basic Research. 2010; 16(2):BR81-88
Investigation of BPC-157's effects on tendon-to-bone healing in a rat Achilles tendon model.
Pentadecapeptide BPC 157 enhances the growth hormone receptor expression
Chang CH, et al. Life Sciences. 2014; 95(1):47-51
Study examining BPC-157's interaction with growth hormone receptor signalling pathways in cell culture models.
Storage and Handling
Lyophilised (unreconstituted):Store at -20°C for long-term stability. Stable at 2-8°C for shorter periods. Protect from light and moisture.
Reconstituted:Store at 2-8°C. Use within 30 days of reconstitution. Avoid repeated freeze-thaw cycles.
Recommended solvent: Bacteriostatic water or sterile water for laboratory use.
Frequently Asked Questions
What is BPC-157 derived from?
BPC-157 is a synthetic peptide based on a partial sequence of a protein found in human gastric juice called Body Protection Compound. It does not occur naturally in its isolated 15-amino-acid form.
What purity should BPC-157 be for research?
Research-grade BPC-157 should be ≥98% purity as verified by HPLC analysis. Certificates of analysis should be available to confirm purity, amino acid composition, and the absence of contaminants.
How should BPC-157 be stored?
In lyophilised form, store at -20°C for maximum stability. Once reconstituted, refrigerate at 2-8°C and use within 30 days. Avoid exposure to light and repeated freeze-thaw cycles.
Disclaimer: This information is compiled from published peer-reviewed literature and is provided for educational and research reference purposes only. It does not constitute medical advice. BPC-157 sold by Enhanced Research Compounds is intended exclusively for in-vitro research and laboratory use. It is not a therapeutic good, is not listed on the ARTG, and is not approved for human or animal consumption.