WHAT IS CJC‑1295?
CJC‑1295 is a synthetic analog of Growth Hormone Releasing Hormone (GHRH), specifically engineered to increase your body’s natural production of growth hormone (GH) through the pituitary gland. It was originally developed to treat growth hormone deficiencies but has become popular in the worlds of anti-aging, bodybuilding, and recovery enhancement due to its extended half-life and stable release profile.
There are two main forms:
CJC‑1295 with DAC (Drug Affinity Complex): Has a half-life of up to 8 days, allowing for just 1–2 weekly injections.
Modified GRF 1‑29 (CJC‑1295 without DAC): Has a much shorter half-life (~30 minutes), requiring multiple daily injections or stacking with other peptides like Ipamorelin.
Unlike synthetic growth hormone, which introduces exogenous GH into the body, CJC‑1295 works by signaling your body to produce more of its own — offering a more natural, physiologically balanced boost.
“CJC‑1295 stimulates GH secretion and increases IGF‑1 levels without significantly elevating prolactin or cortisol, making it favorable for long-term use.”— Walker, Frontiers in Endocrinology
HOW CJC‑1295 WORKS
CJC‑1295 functions by stimulating the pituitary gland to release more growth hormone (GH). It mimics your body’s natural Growth Hormone Releasing Hormone (GHRH) and binds to GHRH receptors in the hypothalamus. Once activated, this pathway encourages pulsatile GH release, leading to a downstream increase in Insulin-like Growth Factor 1 (IGF-1) production from the liver — a key anabolic hormone responsible for muscle growth, fat metabolism, and cellular repair.
The unique advantage of CJC‑1295 lies in its long-acting mechanism, especially in the version with DAC (Drug Affinity Complex). This chemical modification binds the peptide to albumin in the blood, significantly extending its half-life and allowing stable GH pulses for days, rather than minutes.
“CJC‑1295 with DAC has been shown to increase GH and IGF‑1 concentrations for up to 6 days following a single dose.”— Teichman, Journal of Clinical Endocrinology & Metabolism
This makes it especially useful in performance enhancement, anti-aging protocols, and physique optimization — all while mimicking your body’s natural hormone rhythm.
BENEFITS OF CJC‑1295
CJC‑1295 is popular among both athletes and those seeking longevity because of its broad-spectrum growth hormone-boosting effects. When used consistently, it delivers powerful metabolic, aesthetic, and recovery-oriented benefits, including:
➤ Muscle Growth and RecoveryBy increasing IGF-1 and GH levels, CJC‑1295 enhances protein synthesis and promotes muscle hypertrophy. This is especially valuable for athletes and bodybuilders aiming to build lean mass while minimizing fat gain.
“GH stimulates the proliferation and differentiation of myoblasts and enhances amino acid uptake and protein synthesis in muscle.”— Velloso, Brazilian Journal of Medical and Biological Research
➤ Fat LossGrowth hormone mobilizes fat from adipose tissue and boosts the use of fatty acids as energy. CJC‑1295 users often report a noticeable improvement in body composition.
“GH has significant lipolytic effects, reducing fat mass while maintaining or increasing lean body mass.”— Møller et al., Clinical Endocrinology
➤ Improved Sleep and RecoverySince GH is naturally secreted during deep sleep, CJC‑1295 enhances slow-wave sleep, contributing to better overnight recovery, reduced soreness, and improved mental clarity.
➤ Joint and Skin HealthIncreased GH and IGF-1 levels also support collagen synthesis, which can enhance skin elasticity and aid in joint repair — ideal for active individuals or those recovering from injury.
➤ Anti-Aging and Cellular RepairCJC‑1295 is often used in anti-aging stacks for its ability to support mitochondrial health, cellular regeneration, and hormone balance in aging adults.
If you’re looking to amplify these effects, CJC‑1295 is often paired with Ipamorelin or Tesamorelin for synergistic benefits in muscle recovery and fat loss.
CJC 1295 with DAC 5mg
Dosing & Reconstitution Guide
Educational guide for reconstitution and once-weekly dosing protocol
Standard / Gradual Approach (2 mL = 2.5 mg/mL)
WEEK
WEEKLY DOSE (MG)
UNITS (PER INJECTION)
Weeks 1–4
0.3 mg
12 units
Weeks 5–8
0.6 mg
24 units
Weeks 9–12
1 mg
40 units
Weeks 13–16 (Optional)
2 mg
80 units
Ideal for moderate weekly doses (up to ~2 mg). Reconstitute with 2 mL of bacteriostatic water to create a 2.5 mg/mL solution.
Draw 2.0 mL of bacteriostatic water into a sterile syringe.
Inject the water slowly along the vial wall to minimize foaming.
Gently swirl—avoid vigorous shaking.
Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Advanced / Aggressive Approach (1 mL = 5 mg/mL)
WEEK
WEEKLY DOSE (MG)
UNITS (PER INJECTION)
Weeks 1–4
1 mg
20 units
Weeks 5–8
2 mg
40 units
Weeks 9–12
3 mg
60 units
Weeks 13–16 (Optional)
4 mg
80 units
Recommended if aiming for higher doses (1–4 mg weekly). Reconstitute with 1 mL of bacteriostatic water to create a 5 mg/mL solution. Note: Exceeding 80–100 units in one injection may require two separate injections.
Draw 1.0 mL of bacteriostatic water into a sterile syringe.
Slowly inject the water along the vial wall to reduce foaming.
Gently roll or swirl the vial—no vigorous shaking.
Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.