What Is Tesamorelin?
Tesamorelin is a synthetic peptide that mimics Growth Hormone–Releasing Hormone (GHRH). When administered subcutaneously, it binds to GHRH receptors in the anterior pituitary, triggering a pulsatile release of endogenous growth hormone (GH). This spike in GH then stimulates the liver to produce Insulin-like Growth Factor 1 (IGF-1)—the key anabolic mediator responsible for many of Tesamorelin’s body composition and recovery benefits.
Unlike direct human growth hormone (HGH) injections, Tesamorelin maintains the natural feedback loop of the hypothalamic-pituitary axis. That means:
Lower risk of growth hormone receptor desensitization
More physiologic GH levels
Less risk of long-term suppression of natural hormone production
In clinical trials, Tesamorelin increased IGF-1 levels by an average of 181 ng/mL over 26 weeks, significantly improving visceral fat reduction without adversely affecting glucose metabolism (Stanley, NEJM).
This makes Tesamorelin particularly attractive for:
Cutting cycles
Recomposition goals
Recovery from injury
Anti-aging or longevity regimens
Benefits of Tesamorelin
Tesamorelin offers a range of benefits that stem from its ability to elevate natural growth hormone levels in a controlled, pulsatile manner. Unlike synthetic HGH, Tesamorelin works with your body’s hormonal rhythms—making it a favorite among bodybuilders, athletes, and longevity enthusiasts seeking a more balanced approach to growth hormone optimization.
▶ Reduces Visceral Belly FatTesamorelin is FDA-approved for treating excess abdominal fat in HIV patients with lipodystrophy, but its fat-burning effects extend beyond that population. Clinical studies show it targets hard-to-lose visceral fat while preserving subcutaneous fat and lean muscle tissue. This makes it ideal for recomposition or cutting cycles.
▶ Improves Muscle Density and RecoveryBy increasing IGF-1 levels, Tesamorelin enhances muscle protein synthesis, recovery after training, and the repair of microtears—key for bodybuilders, CrossFit athletes, or anyone with intense training schedules. Similar benefits are observed with other GH secretagogues like MK-677 and Ipamorelin.
▶ Enhances Cognitive and Metabolic HealthSome studies suggest Tesamorelin may improve cognitive function and glucose metabolism, making it an appealing tool for biohackers and aging populations looking to improve metabolic resilience.
▶ Supports Anti-Aging and Longevity GoalsTesamorelin's effect on IGF-1 production without disrupting natural hormone feedback makes it one of the safer options for long-term hormone optimization, particularly when compared to synthetic growth hormone injections.
▶ Promotes Faster Recovery from InjuryGrowth hormone and IGF-1 play essential roles in collagen synthesis and connective tissue repair. Tesamorelin may help support joint, tendon, and soft tissue healing, especially when stacked with healing peptides like BPC-157 or TB-500.
Tesamorelin Dosage and Cycle Guidelines
Tesamorelin is typically administered via subcutaneous injection once daily, and timing plays an important role in maximizing its growth hormone–stimulating effects.
▶ Standard DoseThe most common beginner dose is 1 mg per day, injected subcutaneously in the abdominal area. This is the dose used in clinical settings and has been shown to effectively increase IGF-1 levels without significant suppression of endogenous growth hormone.
▶ When To InjectFor optimal results, inject before bedtime. This aligns Tesamorelin’s action with the body’s natural circadian rhythm of growth hormone release, maximizing synergy with endogenous pulses.
▶ Cycle LengthA minimum cycle length of 12–16 weeks is recommended to experience full body composition changes, especially fat loss. Some users extend cycles to 6 months or longer for longevity or anti-aging benefits, under supervision.
▶ Bloodwork MonitoringDue to its IGF-1–raising effect, it’s advised to monitor IGF-1 levels during extended use, especially when stacking with other peptides or growth hormone boosters such as CJC-1295 or MK-677.
▶ Receptor SensitivityTesamorelin maintains GH receptor sensitivity better than exogenous HGH. Still, some protocols include breaks every 12–16 weeks to prevent plateauing and maintain long-term responsiveness.
Important Disclaimer:This product is supplied for laboratory use only. It is not approved for medical, veterinary, or household use. Any discussion of biological function or potential effects is strictly for research reference. By purchasing, you agree to use this material in compliance with all relevant local laws and regulations.
Tesamorelin 5mg
Dosing & Reconstitution Guide
Educational guide for reconstitution and dosing protocol
Standard / Gradual Approach (1 mL = 5 mg/mL)
WEEKS
DAILY DOSAGE (MG)
UNITS (PER INJECTION)
1–4
1 mg (Mon–Fri)
20 units
5–8
1 mg (Mon–Fri)
20 units
A moderate protocol of 1 mg daily (5 days/week), using 1 mL of bacteriostatic water to achieve a 5 mg/mL concentration. Each 1 mg dose corresponds to 0.2 mL (20 units) on a 100-unit insulin syringe.
Draw 1.0 mL of bacteriostatic water into a sterile syringe.
Inject slowly along the vial wall to reduce foaming.
Gently swirl until the powder dissolves—avoid vigorous shaking.
Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Advanced / Aggressive Approach (1 mL = 5 mg/mL)
WEEKS
DAILY DOSAGE (MG)
UNITS (PER INJECTION)
1–4
2 mg (Mon–Fri)
40 units
5–8
2 mg (Mon–Fri)
40 units
A more intensive protocol at 2 mg daily (5 days/week). With 1 mL of reconstitution, each 2 mg dose equals 0.4 mL (40 units). Note that each vial contains 5 mg total; advanced users may need multiple vials per week.
Draw 1.0 mL of bacteriostatic water into a sterile syringe.
Slowly inject along the vial wall to minimize foam.
Gently roll/swirl; avoid shaking vigorously.
Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.